COMPARISON OF HISTOPATHOLOGICAL FINDINGS IN PLACENTAS FROM PARTURIENTS INFECTED OR NOT BY SARS-CoV-2

Authors

  • Maria Letícia Machado Post-Graduate Program in Sciences Applied to Women's Health, Maternidade Escola Januário Cicco (MEJC/EBSERH), Federal University of Rio Grande do Norte, Natal, Brazil.
  • Ronymene de Melo Medeiros Biosciences Center, Federal University of Rio Grande do Norte, Natal, Brazil.
  • Amaxsell Thiago Barros de Souza Department of Pharmacy, Health Sciences Center, Federal University of Rio Grande do Norte, Natal, Brazil.
  • Adson José Martins Vale Department of Medicine, Health Sciences Center, Federal University of Rio Grande do Norte, Natal, Brazil.
  • Ana Clara Pereira Simplício Department of Medicine, Health Sciences Center, Federal University of Rio Grande do Norte, Natal, Brazil.
  • Karina Lílian Gomes Moreira Department of Medicine, Health Sciences Center, Federal University of Rio Grande do Norte, Natal, Brazil.
  • Juliana Dantas de Araújo Santos Camargo Maternidade Escola Januário Cicco (MEJC/EBSERH), Federal University of Rio Grande do Norte, Natal, Brazil.
  • Eduardo Pereira de Azevedo Post-Graduate Program of Biotechnology, Ânima Educação - Universidade Potiguar, Natal, Brazil.
  • Geraldo Barroso Cavalcanti Junior Department of Pharmacy, Health Sciences Center, Federal University of Rio Grande do Norte, Natal, Brazil.
  • Cláudia Nunes Oliveira Department of Pathology, Health Sciences Center, Federal University of Rio Grande do Norte, Natal, Brazil.
  • Ricardo Ney Cobucci UFRN/ Mestrado acadêmico em ciências aplicadas a saúde da mulher

DOI:

https://doi.org/10.16891/2317-434X.v11.e2.a2023.pp1937-1946

Abstract

Objectives: It is not clear whether COVID-19 has any effect on the placenta or even impacts pregnancy outcomes. The aim was to compare the histomorphological characteristics of placentas from parturients with positive and negative PCR for SARS-CoV-2. Methods: Cross-sectional study from May 2021 to March 2022 where histopathological analysis of placentas from women who underwent PCR for the diagnosis of COVID-19, were performed using the Hematoxylin/Eosin staining method. Results: The sample consisted of placentas from thirty parturients, among which ten had been diagnosed with COVID-19 confirmed by PCR (33.3%). Results revealed higher levels of congestion, chronic focal villitis and acute funisitis in placentas from parturients diagnosed with COVID-19. Negative parturients had a higher percentage of intervillous hemorrhage with thrombus formation, dystrophic calcification, placental infarction, and capsular acute deciduitis. Conclusion: No unusual placental histopathological pattern was found among women with positive PCR for SARS-CoV-2. Observational studies with larger samples are warranted.

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Published

2023-08-02

How to Cite

Machado, M. L. ., de Melo Medeiros , R. ., Barros de Souza, A. T. ., Martins Vale, A. J. ., Pereira Simplício, A. C. ., Gomes Moreira, K. L. ., Dantas de Araújo Santos Camargo, J. ., Pereira de Azevedo, E. ., Barroso Cavalcanti Junior, G. ., Nunes Oliveira, C. ., & Cobucci, R. N. (2023). COMPARISON OF HISTOPATHOLOGICAL FINDINGS IN PLACENTAS FROM PARTURIENTS INFECTED OR NOT BY SARS-CoV-2 . Revista Interfaces: Saúde, Humanas E Tecnologia, 11(2), 1937–1946. https://doi.org/10.16891/2317-434X.v11.e2.a2023.pp1937-1946

Issue

Vol. 11 No. 2 (2023):

Section

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