COMPARISON OF HISTOPATHOLOGICAL FINDINGS IN PLACENTAS FROM PARTURIENTS INFECTED OR NOT BY SARS-CoV-2

Authors

  • Maria Letícia Machado Post-Graduate Program in Sciences Applied to Women's Health, Maternidade Escola Januário Cicco (MEJC/EBSERH), Federal University of Rio Grande do Norte, Natal, Brazil.
  • Ronymene de Melo Medeiros Biosciences Center, Federal University of Rio Grande do Norte, Natal, Brazil.
  • Amaxsell Thiago Barros de Souza Department of Pharmacy, Health Sciences Center, Federal University of Rio Grande do Norte, Natal, Brazil.
  • Adson José Martins Vale Department of Medicine, Health Sciences Center, Federal University of Rio Grande do Norte, Natal, Brazil.
  • Ana Clara Pereira Simplício Department of Medicine, Health Sciences Center, Federal University of Rio Grande do Norte, Natal, Brazil.
  • Karina Lílian Gomes Moreira Department of Medicine, Health Sciences Center, Federal University of Rio Grande do Norte, Natal, Brazil.
  • Juliana Dantas de Araújo Santos Camargo Maternidade Escola Januário Cicco (MEJC/EBSERH), Federal University of Rio Grande do Norte, Natal, Brazil.
  • Eduardo Pereira de Azevedo Post-Graduate Program of Biotechnology, Ânima Educação - Universidade Potiguar, Natal, Brazil.
  • Geraldo Barroso Cavalcanti Junior Department of Pharmacy, Health Sciences Center, Federal University of Rio Grande do Norte, Natal, Brazil.
  • Cláudia Nunes Oliveira Department of Pathology, Health Sciences Center, Federal University of Rio Grande do Norte, Natal, Brazil.
  • Ricardo Ney Cobucci UFRN/ Mestrado acadêmico em ciências aplicadas a saúde da mulher

DOI:

https://doi.org/10.16891/2317-434X.v11.e2.a2023.pp1937-1946

Abstract

Objectives: It is not clear whether COVID-19 has any effect on the placenta or even impacts pregnancy outcomes. The aim was to compare the histomorphological characteristics of placentas from parturients with positive and negative PCR for SARS-CoV-2. Methods: Cross-sectional study from May 2021 to March 2022 where histopathological analysis of placentas from women who underwent PCR for the diagnosis of COVID-19, were performed using the Hematoxylin/Eosin staining method. Results: The sample consisted of placentas from thirty parturients, among which ten had been diagnosed with COVID-19 confirmed by PCR (33.3%). Results revealed higher levels of congestion, chronic focal villitis and acute funisitis in placentas from parturients diagnosed with COVID-19. Negative parturients had a higher percentage of intervillous hemorrhage with thrombus formation, dystrophic calcification, placental infarction, and capsular acute deciduitis. Conclusion: No unusual placental histopathological pattern was found among women with positive PCR for SARS-CoV-2. Observational studies with larger samples are warranted.

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Published

2023-08-02

How to Cite

Machado, M. L. ., de Melo Medeiros , R. ., Barros de Souza, A. T. ., Martins Vale, A. J. ., Pereira Simplício, A. C. ., Gomes Moreira, K. L. ., … Cobucci, R. N. (2023). COMPARISON OF HISTOPATHOLOGICAL FINDINGS IN PLACENTAS FROM PARTURIENTS INFECTED OR NOT BY SARS-CoV-2 . Revista Interfaces: Saúde, Humanas E Tecnologia, 11(2), 1937–1946. https://doi.org/10.16891/2317-434X.v11.e2.a2023.pp1937-1946

Issue

Vol. 11 No. 2 (2023):

Section

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