A DISBIOSE DA MICROBIOTA SUBGENGIVAL E O PARTO PREMATURO: UMA REVISÃO SISTEMÁTICA

Abstract

The mechanism of association between periodontitis and increased risk of adverse pregnancy outcomes is still a gap in scientific knowledge. The objective of this systematic review was to systematize knowledge about the association between the level of dysbiosis of the subgingival microbiota and prematurity. This is a cross-sectional, case-control or cohort study were eligible in this systematic review, searched in PubMed / MEDLINE, Web of Science, SCOPUS, Scielo, Lilacs, published until April 2020. This search was conducted using the descriptors: " Periodontitis", "Periodontal Disease", "Oral Dysbiosis", "Oral Microbiome", "Prematurity" and "Preterm". The outcomes were premature birth or premature rupture of membranes. The Newcastle - Ottawa scale was used by two independent reviewers to assess the quality of the studies. As a result, 266 studies were relevant in this systematic review. 59 articles were selected to read the full text. The inclusion criteria were met by seventeen studies: nine case-control studies, three cross-sectional studies and five cohort studies. The findings showed that the increased risk of premature birth may be associated with the degree of periodontal dysbiosis, with the main action being the green complex periodontopathogens, as long as they are grouped with the red and orange complexes. This systematic review indicates that there may be an association between dysbiosis in the subgingival microbiota and prematurity outcomes, highlighting the non-exclusive contribution of traditional key pathogens of periodontitis.